LIGER2: Scalable Single-Cell Integration with On-Disk Datasets
Yichen Wang, Andrew Robbins, Gaurav T. Gadhvi, Joshua D. Welch
LIGER2 improves single-cell data integration by enhancing scalability and efficiency while preserving biological variation.
Author
Boston UniversityORCID 0000-0003-4347-5199Unclaimed ORCID profile · follow to get notified of new preprints
8 papers
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Yichen Wang, Andrew Robbins, Gaurav T. Gadhvi, Joshua D. Welch
LIGER2 improves single-cell data integration by enhancing scalability and efficiency while preserving biological variation.
Jialin Liu, Hiroaki Manabe, Weizhou Qian…·Joshua D. Welch
CytoSignal detects and quantifies ligand-receptor signaling interactions at cellular resolution from spatial transcriptomic data, enabling spatial gradient analysis and temporal dynamics prediction.
Jialin Liu, Yichen Wang, Chen Li…·Joshua Welch
CytoSimplex visualizes cell differentiation trajectories using simplex geometry to represent cell fate commitment and potential in 2D and 3D plots.
Morgane L M D Butler, Nida Pervaiz, Kerry Breen…·Jonathan D. Cherry
This study shows that repetitive head impacts in young athletes cause neuronal loss and neuroinflammation before CTE pathology, with specific cellular changes linked to disease progression.
Yichen Wang, Irzam Sarfraz, Nida Pervaiz…·Joshua David Campbell
SCTK2.0 provides an integrated toolkit for scRNA-seq analysis with a graphical interface, enabling non-programmers to perform end-to-end workflows and generate reproducible reports.
Yichen Wang, Irzam Sarfraz, Wei Kheng Teh…·Joshua David Campbell
The paper introduces MAMS, a metadata standard for single-cell data matrices and analysis workflows, to improve reproducibility and interoperability across datasets.
Rui Hong, Yusuke Koga, Shruthi Bandyadka…·Joshua David Campbell
The paper introduces a pipeline for generating, visualizing, and reporting quality control metrics for scRNA-seq data, improving standardization across platforms.