Lu Lu

Single-cell multi-omic analysis of mesenchymal cells reveals molecular signatures and putative regulators of lung allograft fibrosis

Mapping Cell Fate Transition in Space and Time

This paper introduces TopoVelo, a method to infer spatial and temporal dynamics of cell fate transitions from spatial transcriptomic data, improving spatial coherence and accuracy in cell differentiation and migration analysis.

Lung CD4+ resident memory T cells use airway secretory cells to stimulate and regulate neutrophilic allergic airways disease.

This study identifies lung CD4+ resident memory T cells and their interaction with airway secretory cells as key regulators of neutrophilic allergic airways disease in mice and humans.

Characterization of bronchovascular-bundle mesenchymal stromal cells regulating antibody-secreting cell niche in rejecting lung allografts

The paper characterizes CXCL12-expressing mesenchymal stromal cells and their role in supporting antibody-secreting cell niches in rejecting lung allografts.

Determining susceptibility loci in triple negative breast cancer using a novel pre-clinical model

The paper develops a novel murine model to identify genetic modifiers of triple-negative breast cancer traits and identifies susceptibility loci with potential translational relevance.

GenomeMUSter mouse genetic variation service enables multi-trait, multi-population data integration and analyses

GenomeMUSter integrates and harmonizes mouse genetic variation data across populations to enable multi-trait, multi-population analyses and improve variant-phenotype association studies.

Systems genetics identifies the association between Enc1 and cognitive function in the hippocampus

This study identifies Enc1's association with cognitive function in the hippocampus using systems genetics approaches in BXD mice.

A novel quantitative trait locus implicates Msh3 in the propensity for genome-wide short tandem repeat expansions in mice

The paper identifies a quantitative trait locus on chromosome 13 associated with STR expansion propensity in mice, implicating Msh3 in genome-wide mutation patterns.

A natural mutator allele shapes mutation spectrum variation in mice

The paper identifies a natural mutator allele in mice that increases C>A germline mutations by 50% due to a variant of the Mutyh gene.

PyLiger: Scalable single-cell multi-omic data integration in Python

PyLiger provides a Python implementation of the LIGER method for integrating single-cell multi-omic data, offering faster performance and new features.

Multi-Omic Profiling of the Liver Across Diets and Age in a Diverse Mouse Population

The paper uses multi-omics data from mice to identify gene-environment-age interactions and causal molecular networks linked to longevity.

Gene-by-environmental modulation of longevity and weight gain in the murine BXD family

The paper examines how diet and genetics interact to affect longevity and weight gain in mice, finding that genetic differences significantly influence the impact of high-fat diets on lifespan.

System genetics in the rat HXB/BXH family identifies Tti2 as a pleiotropic quantitative trait gene for adult hippocampal neurogenesis and serum glucose

The paper identifies Tti2 as a gene influencing both adult hippocampal neurogenesis and serum glucose levels using a rat genetic model.

Computational approaches towards reducing contamination in single-cell RNA-seq data

The paper presents two computational methods to reduce contamination in single-cell RNA-seq data, improving clustering and biological interpretation.

Genetic dissection of femoral and tibial microarchitecture

The paper uses high-resolution imaging and QTL analysis to study genetic control of bone microarchitecture in mice, identifying 50 candidate genes with potential roles in bone biology.

The expanded BXD family of mice: A cohort for experimental systems genetics and precision medicine

BXD mouse family doubled to 150 inbred strains segregating over 6 million variants, with roughly 10,000 located recombinations and a public phenome exceeding 7000 traits.

Identification of a functional non-coding variant in the GABAA receptor α2 subunit of the C57BL/6J mouse reference genome: Major implications for neuroscience research

The paper identifies a functional non-coding variant in the GABRA2 gene of the C57BL/6J mouse strain, showing its impact on Gabra2 expression and implications for neuroscience research.

High-Resolution Maps of Mouse Reference Populations

The paper generates high-resolution genetic maps of mouse inbred strains and identifies genetic variations and gene conversions.