Author

Daan C. Swarts

Wageningen University & ResearchORCID 0000-0003-4412-9191Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Bioinformatics· 1 Microbiology· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:bacteria (other)· 2 Research Focus:cell type annotation· 1 Approach:deep learning· 1 Assay:DNA methylation· 1 Organism:multiple species· 1 Research Focus:protein design· 1 Assay:protein sequence· 1

Frequent Co-Authors

Adrie H. WestphaliD· 1 shared Alex J. VecchioiD· 1 shared Ana Alcaraz‐SernaiD· 1 shared Andrew M. WollacottiD· 1 shared Bernard Laurent SchneideriD· 1 shared Brahm J. YachniniD· 1 shared Bruno E. CorreiaiD· 1 shared Casper A. GoverdeiD· 1 shared

Activity by Year

2019-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 36 mutual co-author links

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1 shared paperBioinformatics

Adrie H. WestphalORCID

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3 papers

Recent·Most cited

MicrobiologyMicrobiological ResearchPeer-reviewedAug 31, 2026

Stressostat cultivation of Lactococcus lactis improves lactate stress resistance through mutations in RNA polymerase

Sylviani Hartono, Henriette Lyng Røder, Sjef A. Boeren…·Oscar van Mastrigt

The paper isolates lactate-resistant Lactococcus lactis variants using stressostat cultivation and identifies RNA polymerase mutations as key drivers of resistance through proteome changes.

DOI 10.1016/j.micres.2026.128706

bacteria (other)proteomics

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BioinformaticsbioRxivPreprintSep 30, 2024

✦ In-depth digest

BindCraft: one-shot design of functional protein binders

Martin Pačesa, Lennart Nickel, Christian Schellhaas…·Bruno E. Correia

Hallucinating binders by backpropagating through AlphaFold2 weights gave, across 12 targets, binders in 10-100% of the designs tested per target, mostly at nanomolar affinity.

111 citations

multiple speciesprotein structure

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Molecular BiologyNucleic Acids ResearchPeer-reviewedMay 3, 2019

DNA-guided DNA cleavage at moderate temperatures by Clostridium butyricum Argonaute

Jorrit W. Hegge, Daan C. Swarts, Stanley D. Chandradoss…·John van der OOST

This study characterizes CbAgo, a mesophilic prokaryotic Argonaute that enables DNA-guided DNA cleavage at moderate temperatures using specific siDNA guides.

201 citationstop 3%

bacteria (other)DNA methylation

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