Author

Sascha Koppes-den Hertog

Amsterdam NeuroscienceORCID 0000-0002-7372-8946Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Organism:human· 2 Assay:metabolomics· 2 Approach:statistical model· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:database / resource· 1 Research Focus:differential expression· 1 Approach:experimental assay· 1

Frequent Co-Authors

Martin A. GieraiD· 2 shared Niek Blomberg· 2 shared Rik van der KantiD· 2 shared Adrian M. IsaacsiD· 1 shared Alessandro Ori‬‬iD· 1 shared Alexander J. CammackiD· 1 shared Amber E. TrujilloiD· 1 shared Ashling GibliniD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 35 mutual co-author links

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2 shared papersCell Biology

Martin A. GieraORCID

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2 papers

Recent·Most cited

APOE genotypes differentially remodel the astrocytic lipiddroplet-associated proteome to shape lipid droplet dynamics

Carla Cuní‐López, Jessica T. Root, Ying Hao, Niek Blomberg, Sascha Koppes-den Hertog, Dylan C. Sacks, Amber E. Trujillo, Rodolfo Ghirlando, Isabelle Kowal, Jacob Epstein, Linda G. Yang, Mark Cookson, Elise Marsan, Rik van der Kant, Martin A. Giera, , Priyanka S. Narayan

This study shows APOE genotypes alter astrocytic lipid droplet proteomes and dynamics, with APOE4 showing resistance to lipophagy, suggesting impaired clearance as a mechanism for AD risk.

Nature Communications · Aug 19, 2026Peer-reviewedCell Biology

The Neurolipid Atlas: a lipidomics resource for neurodegenerative diseases uncovers cholesterol as a regulator of astrocyte reactivity impaired by ApoE4

Femke M. Feringa, Sascha Koppes-den Hertog, Lian Y. Wang, Rico J. E. Derks, Iris Daphne Kruijff, Lena Erlebach, Jorin Heijneman, Ricardo Miramontes, Nadine Pömpner, Niek Blomberg, Damien Olivier‐Jimenez, Lill Eva Johansen, Alexander J. Cammack, Ashling Giblin, Christina E. Toomey, , Rik van der Kant

The paper introduces the Neurolipid Atlas, a lipidomics resource for neurodegenerative diseases, revealing that ApoE4 impairs astrocyte reactivity by promoting cholesterol ester accumulation.

Nature Metabolism · Sep 22, 2025Peer-reviewedNeuroscience