C. Cohen

Building optimized single-cell reference atlases with scAtlasTb

The paper introduces scAtlasTb, a framework for building and optimizing single-cell reference atlases, demonstrating its application on three Human Cell Atlas projects.

Fibroblast specialisation across microanatomy in a single-cell atlas of healthy human Achilles tendon

The paper creates a single-cell atlas of the healthy human Achilles tendon, identifying six fibroblast subtypes with distinct spatial distributions and transcriptional profiles.

Exploring cellular changes in ruptured human quadriceps tendons at single-cell resolution

This study uses single-nucleus RNA sequencing to analyze early cellular changes in human quadriceps tendons after rupture, identifying key cell types and pathways involved in the injury response.

Disruption of c-MYC binding and chromosomal looping involving genetic variants associated with ankylosing spondylitis upstream of RUNX3 promoter

The paper investigates how genetic variants associated with ankylosing spondylitis affect c-MYC binding and chromosomal looping near the RUNX3 promoter.

A RUNX3 enhancer polymorphism associated with ankylosing spondylitis influences recruitment of Interferon Regulatory Factor 5 and factors of the Nucleosome Remodelling Deacetylase Complex in CD8+ T-cells

The paper investigates how a polymorphism in a RUNX3 enhancer affects TF binding in CD8+ T-cells, linking it to ankylosing spondylitis risk.