Author

Asifa K. Zaidi

University of AlbertaORCID 0000-0003-4515-1390Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1 Organism:mouse· 1 Assay:proteomics· 1

Frequent Co-Authors

Simonetta SipioneiD· 2 shared Aislinn D. MaguireiD· 1 shared Danny GalleguillosiD· 1 shared Desmond PinkiD· 1 shared Diego Ordóñez· 1 shared E ChavesiD· 1 shared Emily McNamara· 1 shared Jeremies IbangaiD· 1 shared

Activity by Year

2023-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

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2 shared papersCell Biology

Simonetta SipioneORCID

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2 papers

Recent·Most cited

Cell BiologyScience AdvancesPeer-reviewedSep 17, 2025

Gangliosides Modulate the Secretion of Extracellular Vesicles and Their Misfolded Protein Cargo

John Monyror, Vaibhavi Kadam, Luis Carlos Morales…·Simonetta Sipione

This study shows gangliosides modulate EV secretion and misfolded protein cargo, with GM1 enhancing EV release and reducing mutant huntingtin burden in HD models.

12 citations

humanproteomics

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NeurosciencebioRxivPreprintApr 5, 2023

Naive Huntington's disease microglia mount a normal response to inflammatory stimuli but display impaired development of innate immune tolerance that can be counteracted by ganglioside GM1

Noam Steinberg, Danny Galleguillos, Asifa K. Zaidi, Simonetta Sipione

This study shows that naive HD microglia respond normally to inflammation but have impaired tolerance development, which can be reversed by GM1.

DOI 10.1101/2023.04.05.535712

mouseexperimental assay

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