Author

Simonetta Sipione

University of AlbertaORCID 0000-0002-3060-0723Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1 Organism:mouse· 1 Assay:proteomics· 1

Frequent Co-Authors

Asifa K. ZaidiiD· 2 shared Danny GalleguillosiD· 2 shared Noam SteinbergiD· 2 shared Aislinn D. MaguireiD· 1 shared Christopher PoweriD· 1 shared Desmond PinkiD· 1 shared Diego Ordóñez· 1 shared E ChavesiD· 1 shared

Activity by Year

2020-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 23 mutual co-author links

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2 shared papersCell Biology

Asifa K. ZaidiORCID

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Gangliosides Modulate the Secretion of Extracellular Vesicles and Their Misfolded Protein Cargo

John Monyror, Vaibhavi Kadam, Luis Carlos Morales, Diego Ordóñez, Jeremies Ibanga, Asifa K. Zaidi, Emily McNamara, Desmond Pink, Magnus J. Stenlund, Ken Reyes, Aislinn D. Maguire, Jing Huang, Leonardo M. Cortez, Valerie L. Sim, Sue‐Ann Mok, , Simonetta Sipione

This study shows gangliosides modulate EV secretion and misfolded protein cargo, with GM1 enhancing EV release and reducing mutant huntingtin burden in HD models.

Science Advances · Sep 17, 2025Peer-reviewedCell Biology

Naive Huntington's disease microglia mount a normal response to inflammatory stimuli but display impaired development of innate immune tolerance that can be counteracted by ganglioside GM1

Noam Steinberg, Danny Galleguillos, Asifa K. Zaidi, Simonetta Sipione

This study shows that naive HD microglia respond normally to inflammation but have impaired tolerance development, which can be reversed by GM1.

bioRxiv · Apr 5, 2023 · PreprintNeuroscience

Anti-inflammatory role of GM1 and modulatory effects of gangliosides on microglia functions

Danny Galleguillos, Qian Wang, Noam Steinberg, Gaurav Shrivastava, Kamaldeep Dhami, Karin Rubinstein, Fabrizio Giuliani, Matthew A. Churchward, Christopher Power, Kathryn G. Todd, Simonetta Sipione

This study shows that GM1 ganglioside administration reduces microglial inflammation and modulates microglial functions, suggesting therapeutic potential for neurodegenerative diseases.

bioRxiv · Mar 4, 2020 · PreprintNeuroscience