Evarist Planet

The paper identifies functional roles of human KZFPs through overexpression screening and integrative analysis, revealing diverse mechanisms in cellular homeostasis.

The paper identifies the Lipid Oxygen Radical Defense (LORD) pathway and shows it is epigenetically controlled, affecting oxidative stress and ferroptosis.

The paper shows ZNF93, a primate-specific protein, regulates APOBEC3B and influences cancer progression by affecting DNA synthesis and genomic stability.

This study identifies evolutionarily recent transcription factors that influence human cell cycle regulation by affecting gene expression and replication timing.

The paper identifies a noncanonical role for KZFPs in restricting TE-derived regulatory elements to maintain cell-type identity, independent of TRIM28.

This study shows that SCAN domain zinc-finger proteins bind transposon sequences and anchor nucleosomes, affecting chromatin structure and regulatory states.

The paper shows that a transposable element-derived domain in KRAB zinc-finger proteins enables new transcription factor functions through trimerization and condensate formation.

This study identifies degenerate transposable elements in the human genome using ancestral genome reconstruction, finding 1.45 million new elements and their regulatory roles.

The paper identifies TE-eQTLs in colorectal cancer and shows that tumor-specific TEs mediate genetic effects on gene expression, including cancer driver genes.

The paper quantifies TE-mediated cis-regulation using statistical learning, showing TE-embedded CREs influence gene expression and can be predicted from RNA-seq data.

This study examines the genetic features and genomic targets of human KRAB-Zinc Finger Proteins, revealing their role in regulating transposable elements and their evolutionary significance.

The paper identifies a dynamic TE-embedded miRNA expression landscape in human brain development and introduces a web tool for exploring these dynamics.

The paper identifies KZFP:TE transcriptional profiles and TE-derived promoters in the developing human brain, showing their role in neurogenesis.

The paper analyzes the evolutionary dynamics of KRAB zinc finger protein-coding genes in humans, finding that older genes show stronger negative selection while younger genes exhibit more genetic variation and less constraint.

The paper shows that the KZFP/KAP1 system dynamically regulates TEeRS in adult human T cells, affecting gene expression and chromatin states.