Peripheral opioid tolerance involves skin keratinocytes and platelet-derived growth factor type B signaling
Luca Posa, Sophia A. Miracle, Kathryn M. Albers, Matthew J. Fanelli, Angélique Buton, Timmy Le, Anita Khasnavis, Gilles Martin, Ashley K. McDonald, Mackenzie C. Gamble, Salome Fabri-Ruiz, Ryan Wellington Logan, Zachary Freyberg, Stéphanie Puig
This study identifies keratinocytes and PDGF-B/PDGFRβ signaling as key mediators of peripheral opioid tolerance in mice, showing that PDGF-B release from keratinocytes drives tolerance through activation of PDGFRβ in sensory neurons.
bioRxiv · May 14, 2024 · PreprintNeuroscience