Author

Simona S. Ghanem

University of ToledoORCID 0000-0003-4164-6353Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:cell type annotation· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:development & morphogenesis· 1 Research Focus:differential expression· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1 Research Focus:metabolism & bioenergetics· 1

Frequent Co-Authors

Agnes O PortuphyiD· 1 shared Amira F. GoharaiD· 1 shared Angela PyleiD· 1 shared Annabelle E. Hartanto· 1 shared Daniel ErskineiD· 1 shared Getachew Debas BelewiD· 1 shared Haixin Yang· 1 shared Jack P. BainesiD· 1 shared

Activity by Year

2024-2025 · peak 1/yr

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10 top collaborators · 21 mutual co-author links

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1 shared paperPhysiology

Agnes O PortuphyORCID

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2 papers

Recent·Most cited

PhysiologybioRxivPreprintNov 23, 2025

Defective insulin clearance plays a primary role in the pathogenesis of chronic kidney disease in mice with null deletion of Ceacam2 gene

Sivarajan Kumarasamy, Getachew Debas Belew, Agnes O Portuphy…·Sonia Michael Najjar

This study shows that loss of CEACAM2 in mice impairs renal insulin clearance, leading to hyperinsulinemia, insulin resistance, and kidney dysfunction.

1 citation

mouseexperimental assay

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NeurosciencebioRxivPreprintAug 9, 2024

Seed-competent alpha-synuclein pathology in metachromatic leukodystrophy: the expanding spectrum of alpha-synucleinopathy in sphingolipidoses

Simona S. Ghanem, Jade I. Hawksworth, Searlait Thom…·Daniel Erskine

This study examines alpha-synuclein pathology in metachromatic leukodystrophy (MLD) brain tissue, finding seed-competent alpha-synuclein conformers in juvenile-onset cases, similar to Lewy body diseases.

3 citations

humanprotein structure

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