Seed-competent alpha-synuclein pathology in metachromatic leukodystrophy: the expanding spectrum of alpha-synucleinopathy in sphingolipidoses
Simona S. Ghanem, Jade I. Hawksworth, Searlait Thom, Annabelle E. Hartanto, Joseph O’Neill, Janarthanan Ponraj, Said A Mansour, Johannes Attems, Angela Pyle, Lauren R. Johnson, Jack P. Baines, Robert William Taylor, Tiago F. Outeiro, Omar M. A. El‐Agnaf, Daniel Erskine
This study examines alpha-synuclein pathology in metachromatic leukodystrophy (MLD) brain tissue, finding seed-competent alpha-synuclein conformers in juvenile-onset cases, similar to Lewy body diseases.
bioRxiv · Aug 9, 2024 · PreprintNeuroscience