Gail A. Robertson

This study identifies an ER retention motif in hERG1b that enforces a fixed 2:2 stoichiometry in hERG1a/1b channels, with disruption leading to random subunit composition.

This study shows caveolae compartmentalize key proteins in SAN pacemaking, and their disruption leads to heart failure-related arrhythmias.

The paper shows that mRNA interactions promote cotranslational association of heteromeric hERG1a/1b ion channels, with structural diversity and mRNA interactions influencing translation modes.

The paper identifies a specialized ER compartment that sequesters hERG1b subunits, enabling post-translational heteromeric assembly with hERG1a instead of degradation.