Inês Milagre

This study shows that TTF2 removal causes mitotic defects by retaining transcription on chromatin, leading to sister chromatid resolution failure and genome instability.

This paper introduces a method to rejuvenate human fibroblasts by transient reprogramming to the maturation phase of iPSCs, followed by recovery of fibroblast identity, resulting in significant rejuvenation of transcriptome, epigenome, and functional markers.