Edwin A. Rosado-Olivieri

The paper identifies PLSCR1 as a host factor restricting SARS-CoV-2 entry, which recent variants have evolved to bypass, through a CRISPR screen and integration of genetic studies.

This study shows human blastoids undergo gastrulation upon in vitro attachment, replicating the transcriptomic signature of natural human gastrula and suggesting an earlier onset of gastrulation than previously thought.

The paper uses light-induced SHH signaling to self-organize human dorsal-ventral forebrain structures from hESCs and validates this with scRNA-seq.

This paper describes a platform to generate human lung buds from stem cells that mimic lung development and are susceptible to SARS-CoV-2 infection, revealing alveolar cell vulnerability and potential therapeutic targets.