Hans-Heinrich Hoffmann

This paper designs an overlapping variant immunogen pool that elicits broad neutralization against SARS-CoV-2 variants and a chimeric SARS-CoV-1 virus.

This study shows that SARS-CoV-2 infection primes alveolar macrophages for enhanced antiviral responses against influenza A virus through epigenetic changes in IFN-I pathways.

The paper identifies PLSCR1 as a host factor restricting SARS-CoV-2 entry, which recent variants have evolved to bypass, through a CRISPR screen and integration of genetic studies.

The paper validates a heat-inducible promoter from Ixodes scapularis and develops a tick-specific 3xP3 promoter for inducible gene expression in ISE6 cells.

This paper describes a platform to generate human lung buds from stem cells that mimic lung development and are susceptible to SARS-CoV-2 infection, revealing alveolar cell vulnerability and potential therapeutic targets.

The paper identifies TMEM41B as a host factor required for flavivirus infection and shows SNPs in TMEM41B reduce infection in East Asian populations.