Targeting cancer-associated cell surface RNAs with oligonucleotide-drug conjugates enables broad antitumor activity
Cheng Luo, Chen Cheng, Xiaomei Zhao, Jian Zhou, Zhiwen Jing, Qingchuan Ma, Lingyuan Ye, Keyao Zhu, Linfeng Zhao, Han Xu, Hu Zeng
This study develops CIRCmap to profile cell-surface and intracellular RNAs, identifies cancer-associated csRNAs, and demonstrates oligonucleotide-drug conjugates targeting these RNAs show broad antitumor activity.
bioRxiv · May 12, 2026 · PreprintCell Biology