Audrey Forest

Whole genome duplication through mitotic slippage causes nuclear instability

The paper investigates how different routes to whole-genome duplication (WGD) affect nuclear stability, finding that mitotic slippage uniquely causes nuclear instability.

HIRA defines early replication initiation zones independently of their genome compartment

The paper shows HIRA regulates early replication initiation zones independently of chromatin accessibility, histone marks, and 3D compartment organisation.

Non-centromeric CENP-A epigenetically regulates epithelial-mesenchymal plasticity and heterogeneity in human cells

This study shows that CENP-A, a centromeric histone variant, epigenetically regulates epithelial-mesenchymal plasticity and heterogeneity in human cells through non-centromeric mechanisms.

H3.3 deposition counteracts the replication-dependent enrichment of H3.1 at chromocenters in embryonic stem cells

The paper shows H3.3 deposition counteracts H3.1 enrichment at chromocenters in ESCs, affecting heterochromatin stability and cell survival.

HIRA-dependent provision of histone H3.3 in active chromatin ensures genome compartmentalisation

This study shows that HIRA-dependent histone H3.3 deposition maintains 3D genome compartmentalisation in active chromatin, independent of histone PTMs.

Regulation of replicative histone RNA metabolism by the histone chaperone ASF1

The paper shows ASF1 regulates replicative histone RNA metabolism by affecting RNA processing and stability, ensuring proper histone dosage during DNA replication.