Jacky Chuen

This study shows that partial deletion of RpS12 in mice causes defects in erythropoiesis and hematopoietic stem cell maintenance, leading to embryonic lethality and pancytopenia.

This study identifies Xrp1 as a master regulator that triggers cell competition and translation deficits in response to ribosomal stress.

The paper shows that cell competition eliminates segmentally aneuploid cells in Drosophila imaginal discs through the RpS12-Xrp1 pathway, dependent on differences in ribosomal protein gene dose.