Alessandro Cuomo

Endocytic control of cell-autonomous and non-cell-autonomous functions of p53

This study shows that NUMB's Ex3 exon directs it to the plasma membrane, forming a complex with SNX9 that recruits and transports p53 via exosomes, enabling p53-dependent transcriptional activity in recipient cells.

Targeting GL-Lect driven endocytosis to suppress cell plasticity in breast cancer

This study identifies GL-Lect driven endocytosis as a driver of metastatic plasticity in breast cancer and shows pharmacologic inhibition can suppress invasive phenotypes.

METTL9 sustains vertebrate neural development primarily via non-catalytic functions

The paper investigates METTL9's role in vertebrate neural development, finding its non-catalytic functions sustain neurogenesis through secretory pathway modulation.

GTF2I dosage regulates neuronal differentiation and social behavior in 7q11.23 neurodevelopmental disorders

This study shows that GTF2I dosage affects neuronal differentiation and social behavior in 7q11.23 neurodevelopmental disorders using patient-derived organoids and mouse models.

ProMetheusDB: an in-depth analysis of the high-quality human methyl-proteome

The paper presents a high-quality human methyl-proteome dataset generated using hmSILAC and a machine learning tool, showing improved identification of methyl-peptides and novel histone methylation marks.