Nicholas Jones

The paper shows that PD patients have altered CD4+ T cell responses to fasting/refeeding, leading to impaired neuro-immune signaling through a dysfunctional metabolic program in neurons.

This paper shows that inhibiting ABHD11 reduces T cell cytokine production and alleviates autoimmunity by altering sterol metabolism and LXR activation.

This study uses SCENITH to show cryopreservation affects immune cell metabolism, favoring glycolysis and impairing oxidative phosphorylation, but still allows for distinct metabolic profiling of cell subsets.

This study shows PRMT5 inhibition targets MNA neuroblastoma by altering splicing of nutrient sensors and epitranscriptome regulators, leading to growth inhibition and apoptosis.

This study shows that iron deficiency in people with obesity impairs NK cell mitochondrial function and cytokine production.