Elçin Ünal

Vac8-driven vacuolar remodeling primes mega-autophagy and safeguardsgamete developmental competence

This study identifies Vac8 as a regulator of vacuolar remodeling during meiosis, which primes mega-autophagy to ensure gamete developmental competence.

Tom70-mediated mitochondria-nuclear envelope contacts regulate nuclear pore complex inheritance during gametogenesis

The paper identifies Tom70 as a regulator of nuclear pore complex exclusion during gametogenesis in yeast by mediating mitochondria-nuclear envelope contacts.

Prefoldin function links meiotic chromosome segregation with cellular remodeling and reveals tubulin sensitivity of the meiotic spindle

This study identifies Gim3 as a critical regulator of meiotic chromosome segregation in budding yeast, revealing its role in spindle sensitivity to tubulin levels and meiotic cellular remodeling.

The UPR drives gametogenesis via an unexpected response, coordinating translation and ER structure

The paper shows that the endogenous UPR in budding yeast is essential for gametogenesis, coordinating translation and ER structure through a distinct mechanism from exogenous UPR activation.

Glutamine codon-driven translational readthrough reveals context-dependent stop codon decoding fidelity

The paper shows that glutamine codon context and abundance influence stop codon readthrough in yeast, with a QXQ motif and global glutamine content affecting readthrough efficiency.

A role for selective autophagy of the ER in gametogenic rejuvenation revealed by microfluidics-based lifespan profiling

The paper introduces a high-throughput microfluidic assay to study gametogenic rejuvenation in yeast and identifies Atg39 and Atg40 as molecular determinants of lifespan resetting.

A Conserved Disruption of the Nuclear Permeability Barrier in Meiosis is Controlled by a Kinase-Phosphatase Pair in Saccharomyces cerevisiae

The paper identifies a conserved meiotic mechanism called virtual nuclear envelope breakdown (vNEBD) in yeast, regulated by Ime2 kinase and Gip1 phosphatase.

Swi/Snf Chromatin Remodeling Regulates Transcriptional Interference and Gene Repression

This study identifies the Swi/Snf chromatin remodeling complex as essential for LUTI-based transcriptional interference and gene repression through co-transcriptional nucleosome remodeling.

Multi-signal regulation of the GSK-3β homolog Rim11 governs meiosis entry in yeast

The paper shows how Rim11 integrates signals from PKA, TORC1, and Ime1 to regulate Ume6 phosphorylation and drive meiotic gene expression in yeast.

Control of meiotic entry by dual inhibition of a key mitotic transcription factor

The paper identifies two mechanisms that restrict SBF activity during meiotic entry in budding yeast, highlighting their role in regulating gene expression and meiotic progression.

The Transcriptional Regulator Ume6 is a Major Driver of Early Gene Expression during Gametogenesis

This study resolves the mechanism of early meiotic gene activation by showing that Ime1 and Ume6 function as a coactivator complex, with Ume6 directly regulating EMG expression.

Comprehensive analysis of meiosis-derived cDNA libraries reveals gene isoforms and mitochondrial proteins important for competitive fitness

The paper constructs and analyzes meiotic cDNA libraries in yeast to identify gene isoforms and mitochondrial proteins affecting competitive fitness and respiration.

Integrated Genomic Analysis Reveals Key Features of Long Undecoded Transcript Isoform (LUTI)-based Gene Repression

The paper identifies LUTI candidates during meiotic prophase and shows that LUTI-based repression integrates translational and transcriptional mechanisms.

Tunable Transcriptional Interference at the Endogenous Alcohol Dehydrogenase Gene Locus in Drosophila melanogaster

The paper shows that transcriptional interference at the endogenous Adh locus in Drosophila melanogaster is developmentally regulated and tunable through distal promoter activity.

Aurora B-dependent Ndc80 Degradation Regulates Kinetochore Composition in Meiosis

This study shows that Aurora B-dependent phosphorylation of Ndc80 promotes its degradation during meiosis, regulating kinetochore composition and preventing chromosome mis-segregation.

Evidence for an Integrated Gene Repression Mechanism based on mRNA Isoform Toggling in Human Cells

The paper identifies an integrated gene repression mechanism in human cells through mRNA isoform toggling at the MDM2 locus, similar to yeast.