Bruno Canard

This paper investigates the mechanism of 6-ethyl-modified 7-deazaadenosine (EDA) as a coronavirus inhibitor, showing it stalls viral polymerase without causing mutagenesis.

This paper reveals the activation pathway of bemnifosbuvir to its active form AT-9010, showing the required enzymes and structural insights into the process.

This study identifies critical residues in the nsp14 N7-MTase domain essential for betacoronavirus replication and suggests potential drug targets.

The paper identifies a Rossman fold N7-guanine cap methyltransferase in the Orf1a of Tobaniviridae, suggesting a genetic marker for this viral family.

This paper investigates the RNA exonuclease activity of Arenavirus ExoN, showing it edits genomic RNA and links to genome stability rather than innate immune suppression.