Ilona Rissanen

The paper shows that SARS-CoV-2 resistance to broadly neutralizing antibodies is due to altered spike conformational dynamics, not epitope mutations.

This study engineers multivalent antibody fragments, resolves their crystal structures, and shows diabodies can enhance crystallization of antibody-antigen complexes.

This paper determines the crystal structure of an engineered antibody diabody bound to rabies virus glycoprotein, revealing a conserved epitope and mechanism of neutralization.

The paper identifies a critical epitope on PUUV Gc targeted by neutralizing antibodies and shows that mutations in this region confer neutralization escape.