Ashwini Kedari

This study determines the structural basis of Cx45 gating and Ca2+ regulation using cryo-EM, revealing a dual steric-electrostatic mechanism.

This study engineers multivalent antibody fragments, resolves their crystal structures, and shows diabodies can enhance crystallization of antibody-antigen complexes.

This paper determines the crystal structure of an engineered antibody diabody bound to rabies virus glycoprotein, revealing a conserved epitope and mechanism of neutralization.

The paper identifies a critical epitope on PUUV Gc targeted by neutralizing antibodies and shows that mutations in this region confer neutralization escape.