Yunming Wu

Whole-brain axon tracing in 110 mouse brains divides raphe serotonin neurons into five projectomic groups, tied to transcriptome plus position and to dissociable behavioral effects of depletion.

This study identifies conserved and clade-specific hypothalamic cell types across vertebrates using single-cell transcriptomics, revealing conserved transcription factors and rewired regulatory linkages.

Connectome-seq maps neuronal connectivity at single-synapse resolution using barcoding and sequencing, revealing molecular markers in connected neurons.

This study shows that neural representations of hunger and thirst are distinct in neonatal mice before they can seek food and water separately, and these representations persist despite environmental changes.

This paper introduces Expansion Spatial Transcriptomics to improve spatial resolution and capture efficiency in spatial transcriptomics by expanding tissue before transcriptome capture, demonstrated on mouse brain samples.

The paper identifies Fzd1 as a master regulator of the critical period for olfactory imprinting, showing its role in closing the period to lock in permanent odor memory circuits.

This study shows that innate odor preference in mice requires both spontaneous neural activity and sensory experience during a critical period, with ectopic projections altering odor valence.

The paper shows that innate odor valence is not encoded through insulated channels but is instead re-coded via crosstalk among mitral/tufted cells in the olfactory bulb, abolishing innate behavioral responses to mixed odors.

This study shows TGS1 is essential for snRNA 3' end processing and its loss causes neurodegeneration, which can be mitigated by human TGS1 expression in model organisms.