Nicolas James Wheeler

Distinct antischistosomal profiles of antimalarials and TRP agonists

This study compares the antischistosomal effects of antimalarials and TRP agonists using RNA-seq and efficacy tests in mice, finding distinct transcriptional responses and retained activity against praziquantel-resistant parasites.

Deep phenotypic profiling uncovers cryptic effects of antifilarial drugs

This study uses high-content imaging and mass spectrometry to analyze antifilarial drug effects on microfilariae and adult worms, revealing stage-dependent responses and secretory changes.

Tissue-specific distribution of eggs in the definitive host drives transcriptomic and behavioral differences in Schistosoma mansoni miracidia

The paper compares miracidia from liver and intestine-derived eggs of Schistosoma mansoni, finding transcriptomic and behavioral differences that highlight the impact of egg source on experimental outcomes.

Quantitative ethology of schistosome miracidia characterizes a conserved snail peptide that inhibits penetration

This study develops a system to track schistosome miracidia behavior and identifies a snail peptide that inhibits their penetration.

A graphical user interface for wrmXpress 2.0 streamlines helminth phenotypic screening

The paper develops a graphical user interface for wrmXpress 2.0 to streamline image-based phenotypic screening of helminths, making analysis more accessible without requiring command-line expertise.

A high-throughput nematode sensory assay reveals an inhibitory effect of ivermectin on parasite gustation

The paper introduces a microfluidics-based nematode sensory assay to study gustation and shows that ivermectin inhibits gustatory ability in parasitic nematodes.

Pharmacological profiling of a Brugia malayi muscarinic acetylcholine receptor as a putative antiparasitic target

The paper profiles muscarinic acetylcholine receptors in Brugia malayi to assess their potential as antiparasitic targets using functional assays and expression mapping.

Ivermectin inhibits extracellular vesicle secretion from parasitic nematodes

This study shows that ivermectin inhibits extracellular vesicle secretion from parasitic nematodes, suggesting a potential mechanism for its therapeutic effect against lymphatic filariasis.

Long-read RNA sequencing of human and animal filarial parasites improves gene models and discovers operons

The paper uses long-read RNA sequencing to improve gene models and discover operons in two filarial parasites, enhancing functional annotation and target identification.

Comparative genomics of the major parasitic worms

This paper compares genomes of 81 nematode and platyhelminth species to identify gene families related to parasitism and prioritize new drug targets.