Mostafa Zamanian

This study compares the antischistosomal effects of antimalarials and TRP agonists using RNA-seq and efficacy tests in mice, finding distinct transcriptional responses and retained activity against praziquantel-resistant parasites.

This study develops high-throughput assays to profile insecticide responses in mosquito larvae, testing compounds and establishing baseline dose-response curves.

This study uses high-content imaging and mass spectrometry to analyze antifilarial drug effects on microfilariae and adult worms, revealing stage-dependent responses and secretory changes.

CELeidoscope enables multiplexed cell-type isolation in C. elegans using a single strain with spectrally distinct fluorescent tags, validated by transcriptomic analysis.

The paper isolates Streptomyces from cadaveric fly larvae, identifies bioactive compounds, and demonstrates their anthelmintic activity against Brugia malayi.

This study identifies labradorin 1, an indole compound from Pseudomonas sp. TE4607, as a nematicidal agent effective against both free-living and parasitic nematodes.

This study tests fenbendazole efficacy against ascarid parasites in poultry, finding resistance in one Ascaridia galli isolate and all Heterakis gallinarum isolates.

This paper develops an optimized topical gel for rabies vaccine delivery to vampire bats, showing high colony uptake and stability under various temperatures.

This study investigates the transcriptional effects of meclonazepam on Schistosoma mansoni, showing it causes tegument damage and apoptosis, with gene expression patterns similar to but distinct from praziquantel.

The paper develops a graphical user interface for wrmXpress 2.0 to streamline image-based phenotypic screening of helminths, making analysis more accessible without requiring command-line expertise.

This paper identifies a cytochrome P450 gene variant that contributes to benzimidazole resistance in nematodes, independent of beta-tubulin mutations.

This study investigates Wolbachia's effect on ZIKV infection in Ae. aegypti using transcriptomics and viral sequencing, finding no clear transcriptional profile or evidence of ZIKV escape.

The paper introduces a microfluidics-based nematode sensory assay to study gustation and shows that ivermectin inhibits gustatory ability in parasitic nematodes.

The paper profiles muscarinic acetylcholine receptors in Brugia malayi to assess their potential as antiparasitic targets using functional assays and expression mapping.

The paper identifies three genomic regions in C. elegans associated with natural variation in macrocyclic lactone response, including two novel loci and one previously known locus.

This study shows that ivermectin inhibits extracellular vesicle secretion from parasitic nematodes, suggesting a potential mechanism for its therapeutic effect against lymphatic filariasis.

The paper uses long-read RNA sequencing to improve gene models and discover operons in two filarial parasites, enhancing functional annotation and target identification.

This paper compares genomes of 81 nematode and platyhelminth species to identify gene families related to parasitism and prioritize new drug targets.

This study describes the chemosensory anatomy and behaviors of Brugia malayi, revealing simpler structures and chemotactic responses to host-related stimuli.

The paper identifies QTL underlying toxin response variation in C. elegans and validates their contributions through experimental assays.

The paper identifies QTL associated with benzimidazole resistance in nematodes using genetic mapping and phenotyping.