Francisco F. Cavazos

This study identifies RNA binding domains in HNRNPR, showing that RRM3 and a C-terminal charged region are critical for RNA binding, and reveals specific interactions with G-quadruplexes.

The paper characterizes RNA G-quadruplex stability and recognition by ligands and proteins using a synthetic library and reverse-transcriptase stop sequencing.

The paper investigates how tandem RNA-binding domains in three proteins mediate RNA selectivity through in vitro assays and in vivo validation, showing that intrinsic specificities and cellular context influence target discrimination.

The paper examines interspecies differences in RNA-protein interactions using the neuronal RNA binding protein UNK, finding conserved binding patterns and species-specific sequence determinants.