Maria M. Aleman

This study identifies RNA binding domains in HNRNPR, showing that RRM3 and a C-terminal charged region are critical for RNA binding, and reveals specific interactions with G-quadruplexes.

The paper characterizes RNA G-quadruplex stability and recognition by ligands and proteins using a synthetic library and reverse-transcriptase stop sequencing.

This study identifies multi-level molecular changes in ER-positive breast cancer cells treated with palbociclib, revealing feedback loops and alternative splicing that suggest new therapeutic strategies.

The paper investigates how tandem RNA-binding domains in three proteins mediate RNA selectivity through in vitro assays and in vivo validation, showing that intrinsic specificities and cellular context influence target discrimination.

The paper identifies iron-sensitive RNA regulation by poly C binding proteins through transcriptome analysis under low iron conditions.

The paper examines interspecies differences in RNA-protein interactions using the neuronal RNA binding protein UNK, finding conserved binding patterns and species-specific sequence determinants.