Mei‐Sheng Xiao

DEPICT predicts drug-induced transcriptional responses from gene expression and drug data, outperforming existing methods and enabling drug screening and synergy discovery.

The paper introduces CRASP-Seq, a method to identify gene regulators of alternative splicing, and finds ZNF207 regulates LMNA splicing in progeria by interacting with U1 snRNP.

The paper identifies the Integrator complex as a regulator of transcription by cleaving nascent mRNAs, revealing its role in attenuating gene expression during copper stress.