Dongming Liang

The paper introduces spatial NT-seq to map RNA turnover and stability in the mouse brain, revealing spatial heterogeneity and kinetics scaling mechanisms in response to ECS.

scNT-seq2 improves time-resolved single-cell RNA sequencing by enhancing sensitivity and scalability for studying transcriptional dynamics.

The paper shows that IntS6 recruits PP2A to regulate transcription termination efficiency at specific genes, highlighting the phosphatase module's selective role in Integrator complex function.

The paper compares off-target effects of CRISPR/Cas13 effectors in eukaryotic cells, finding significant variability in specificity across different effectors and cell types.

The paper identifies the Integrator complex as a regulator of transcription by cleaving nascent mRNAs, revealing its role in attenuating gene expression during copper stress.