Timon Seeger

The paper develops a cytosine base editing workflow to generate quality-controlled multiplex-knockout hiPSC lines for studying disease mechanisms.

This study shows cardiomyocytes use GBP5 to regulate both pro- and anti-inflammatory responses to IFNγ through the AIM2/CASP1 pathway and GBP5/TGFβ axis.

This study identifies MLP as a non-canonical RNA-binding protein in cardiomyocytes and shows its RNA-dependent interaction with cytoskeletal complexes.

The paper uses single molecule long-read sequencing to analyze transcriptomes in heart failure patients and controls, identifying novel isoforms and convergent isoform changes across different cardiomyopathy types.

The paper identifies NMD targets and activity in cardiomyocytes using SMG1 inhibition and RNA sequencing, showing conserved targets and reduced efficiency with UPF1/UPF2 knockdown.