Author

Michael Shadpour

Harvard UniversityORCID 0009-0000-4127-3927Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:differential expression· 2 Organism:human· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Assay:scRNA-seq· 1 Approach:statistical model· 1

Frequent Co-Authors

Alexandru M. PleşaiD· 2 shared George McDonald ChurchiD· 2 shared Amy J. WagersiD· 1 shared Andrew L. JiiD· 1 shared Anna MandinovaiD· 1 shared Antonio del SoliD· 1 shared Asaf Ashkenazy-Titelman· 1 shared Carol V. de Magalhaes· 1 shared

Activity by Year

2023-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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2 shared papersSynthetic Biology

Alexandru M. PleşaORCID

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2 papers

Recent·Most cited

Synthetic BiologyJournal of Investigative DermatologyPeer-reviewedJul 21, 2026

Human skin rejuvenation via mRNA

Li Li, Zhengkuan Tang, Xavier Portillo…·George McDonald Church

This paper presents a single-cell atlas of skin aging and identifies ATF3 as a regulator of aging, leading to an mRNA-based treatment that reduces cell senescence and enhances skin rejuvenation.

6 citationstop 3%

humanscRNA-seq

𝕏 PostBluesky

GenomicsbioRxivPreprintNov 13, 2023

Transcriptomic reprogramming screen identifies SRSF1 as rejuvenation factor

Alexandru M. Pleşa, Sascha Jung, Helen H. Wang…·George McDonald Church

This study identifies SRSF1 as a rejuvenation factor through transcriptomic reprogramming, showing it improves cellular function and is linked to longevity.

8 citations

humanbulk RNA-seq

𝕏 PostBluesky