Antonio del Sol

The paper introduces BoNesis, a tool for inferring Boolean networks from transcriptome data to model cellular differentiation and reprogramming, demonstrating its application in hematopoiesis and adipocyte/osteoblast differentiation.

The paper develops human tri-lineage brain microtissues composed of neurons, astrocytes, and microglia, showing they recapitulate cell-cell interactions and pathological processes.

The paper shows glycolytic flux promotes rod photoreceptor differentiation by regulating Wnt signaling in murine retinal progenitor cells.

The paper identifies repurposable drugs for mitochondrial disease by using deep learning to screen for compounds that improve neuronal commitment and neurogenesis in Leigh syndrome organoids.

This study shows Pten and Dscam regulate amacrine cell spacing through endocytic trafficking of cell adhesion and signaling molecules, with altered extracellular vesicles and Wnt signaling in Pten mutants.

This study identifies SRSF1 as a rejuvenation factor through transcriptomic reprogramming, showing it improves cellular function and is linked to longevity.

This study identifies cell-type-specific epigenetic changes in TNXB in Alzheimer's disease using bulk and single-cell analyses of the dorsal raphe nucleus.

The paper identifies a proneural gene combinatorial code that diversifies neocortical neural progenitor cells through gene regulatory networks and cell fate decisions.

RNetDys identifies disease-related impaired regulatory interactions due to SNPs by analyzing multi-OMICS data and cell-type specific GRNs.

ChemPert provides a database of transcriptional responses in non-cancer cells to improve drug response predictions for non-cancer diseases.

The paper shows Neurog2 and Ascl1 genes regulate cortical progenitor differentiation and folding through Notch signaling in lissencephalic brains.

The paper uses single-cell RNA sequencing to analyze cardiac progenitor cells during normal and abnormal cardiogenesis, identifying transcriptional changes linked to congenital heart defects.

The paper identifies a conserved LPA signaling pathway that controls apical membrane size and maintains epithelial organization in neuroepithelial rosettes.