Author

Hanspeter Niederstrasser

The University of Texas Southwestern Medical CenterORCID 0009-0000-4599-9135Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

Click to filter author papers

Biochemistry· 1 Genomics· 1 Microbiology· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:experimental assay· 3 Research Focus:drug response / drug discovery· 2 Research Focus:benchmarking· 1 Approach:deep learning· 1 Organism:human· 1 Organism:plant (other)· 1 Assay:scRNA-seq· 1 Assay:structural biology· 1

Frequent Co-Authors

Bruce A. PosneriD· 3 shared Joseph M. ReadyiD· 2 shared Abir MajumdariD· 1 shared Adam OsinskiiD· 1 shared Adele M. LehaneiD· 1 shared Aloysus K. LawongiD· 1 shared Anjana SundarrajaniD· 1 shared Arturo Casas Jr· 1 shared

Activity by Year

2025-2025 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

3 shared papersGenomics

Bruce A. PosnerORCID

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

GenomicsStem Cell ReportsPeer-reviewedNov 13, 2025

Benchmarking and optimizing Perturb-seq in differentiating human pluripotent stem cells

Sushama Sivakumar, Yihan Wang, Sean C. Goetsch…·Nikhil V. Munshi

This study benchmarks and optimizes Perturb-seq in human pluripotent stem cells, identifying shared regulatory networks during cardiomyocyte differentiation.

9 citations

humanscRNA-seq

𝕏 PostBluesky

MicrobiologyACS Infectious DiseasesPeer-reviewedSep 8, 2025

Identification of α-azacyclic acetamide-based inhibitors of P. falciparum Na+ pump (PfATP4) with fast-killing asexual blood-stage antimalarial activity by phenotypic screening

Arturo Casas Jr, Leah S. Imlay, Vandana Thathy…·Margaret A. Phillips

This study identifies new antimalarial compounds targeting PfATP4 through phenotypic screening, showing fast-killing activity and resistance patterns consistent with PfATP4 inhibition.

4 citations

plant (other)experimental assay

𝕏 PostBluesky

BiochemistryJournal of Biological ChemistryPeer-reviewedMar 4, 2025

Covalent inhibition of the SARS-CoV-2 NiRAN domain via an active-site cysteine

Genaro Hernandez, Adam Osinski, Abir Majumdar…·Vincent S. Tagliabracci

The paper identifies NCI-2, a covalent inhibitor of the SARS-CoV-2 NiRAN domain, and presents a structural blueprint for drug design.

2 citations

virusstructural biology

𝕏 PostBluesky