Adele M. Lehane

Mutations within and outside the PfFNT transport pathway drive MMV007839 resistance in Plasmodium falciparum

The paper identifies two new mutations in PfFNT conferring resistance to MMV007839 and shows how these mutations destabilize inhibitor binding.

A proton transfer mechanism in the malaria parasite lactate/H+ symporter reveals a channel-like transporter without conformational changes

This paper identifies a proton transfer mechanism in the malaria parasite lactate/H+ symporter, showing it functions as a transporter without conformational changes and can switch between transporter and channel modes.

PfATP2 is an essential flippase on the Plasmodium falciparum surface that influences parasite sensitivity to antiplasmodial compounds

This study identifies PfATP2 as a surface flippase essential for Plasmodium falciparum growth and a target of antimalarial compounds, showing its role in phosphatidylserine internalization and drug sensitivity.

Identification of α-azacyclic acetamide-based inhibitors of P. falciparum Na+ pump (PfATP4) with fast-killing asexual blood-stage antimalarial activity by phenotypic screening

This study identifies new antimalarial compounds targeting PfATP4 through phenotypic screening, showing fast-killing activity and resistance patterns consistent with PfATP4 inhibition.