Lee-Ann Van de Velde

TIRTL-seq provides a scalable, cost-effective method for paired TCR repertoire sequencing, enabling accurate identification of TCR chain pairings and clonotype dynamics in large cohorts.

This study shows that targeting RBM39 with indisulam promotes natural killer cell activity and eradicates neuroblastoma regardless of cellular state plasticity.

This study shows that IL4i1 metabolites from immune cells suppress ferroptosis in neuroblastoma cells by scavenging free radicals and activating NRF2, promoting tumor survival.