Theo Redfern-Nichols

This study compares the functional and structural properties of the intracellular agonist PCO371 with the extracellular peptide agonist PTH 1-34 at the PTH1R, revealing PCO371's non-biased signaling profile and lower potency.

This study shows that agonist efficacy at the {beta}2AR is determined by differences in receptor affinity for Gs protein, not ligand binding kinetics.

This study investigates rare disease variants in Gs, a G protein, using multidimensional approaches to reveal how mutations affect receptor-Gs coupling and signaling defects.