Martial Sevéno

Multi-omics characterization of IDH-mutant astrocytoma-derived cell lines reveals NOTCH-regulated plastic quiescent astrocyte-like state

The paper establishes and characterizes IDH-mutant astrocytoma cell lines, revealing NOTCH-regulated plasticity between astrocyte-like and oligodendrocyte-like states.

A large-scale analysis of the R2TP chaperone network reveals its contribution to the assembly of INO80, SRCAP and TIP60

The paper identifies RPAP3 and PIH1D1 as R2TP subunits and shows their role in assembling INO80, SRCAP, and TIP60 complexes through physical interactions and functional validation.

Physical interaction with Ephrin B1 promotes CXCR4 intracellular localization and oncogenic potential

This study identifies Ephrin B1 as a key mediator of CXCR4 tumorigenic signaling by promoting its intracellular localization and inhibiting surface expression and signaling.

Endothelin Signaling via EDNRB receptor Reduces Proliferation and Promotes Proneural-to-Mesenchymal Transition in Gliomas

This study identifies endothelin signaling via EDNRB as a regulator of glioma cell proliferation and proneural-to-mesenchymal transition, with distinct receptor expression and functional roles in different tumor subtypes.

Dengue virus harnesses mosquito Syntenin to load and secrete viral RNA into salivary exosomes

This study identifies how dengue virus uses mosquito Syntenin to package and secrete viral RNA into salivary exosomes, revealing a mechanism for viral RNA incorporation into extracellular vesicles.

Co-translational determination of quaternary structures in chaperone factories

The paper identifies co-translational interactions between R2TP and client proteins, revealing a mechanism called co-translational chaperone channeling that facilitates early assembly of protein complexes.

Hippo/YAP1 Signaling Regulates the Oligodendrocyte-Astrocyte Fate Switch and Ependymal Gene Expression in Adult Spinal Cord Stem Cells

This study identifies YAP1's role in regulating oligodendrocyte-astrocyte fate switch and ependymal gene expression in adult spinal cord stem cells through in vitro experiments and multi-omic profiling.

A reciprocal interplay between 5-HT2A and mGlu5 receptors underlies neuroplasticity

This study shows that psychedelics induce neuroplasticity through a reciprocal interaction between 5-HT2A and mGlu5 receptors involving Shank3.

Co-translational sorting enables a single mRNA to generate distinct polysomes with different localizations and protein fates

The paper shows that co-translational interactions sort β-catenin mRNAs into distinct polysome populations with different localizations and protein fates.