Author

Sumeet A. Khetarpal

Harvard UniversityORCID 0009-0000-8269-6889Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Genomics· 1 Molecular Biology· 1 Physiology· 1

Signature Assays, Organisms & Methods

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Research Focus:differential expression· 2 Approach:experimental assay· 2 Organism:mouse· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Research Focus:fine-mapping· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

Ariana Vargas‐CastilloiD· 2 shared Bruce M. SpiegelmaniD· 2 shared Hans‐Georg SprengeriD· 2 shared Melanie J. MittenbühleriD· 2 shared Steven P. GygiiD· 2 shared Yizhi SuniD· 2 shared Aarti H. AsnaniiD· 1 shared Abhilash JayarajiD· 1 shared

Activity by Year

2018-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 42 mutual co-author links

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2 shared papersPhysiology

Ariana Vargas‐CastilloORCID

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3 papers

Recent·Most cited

PhysiologyNature Cardiovascular ResearchPeer-reviewedSep 24, 2025

Cardiomyocyte PGC-1α enables physiological adaptations to endurance exercise through suppression of GDF15 and cardiac atrophy

Sumeet A. Khetarpal, Haobo Li, Tevis Vitale…·Anthony Rosenzweig

This study shows that cardiomyocyte PGC-1α is essential for cardiac adaptation to endurance exercise by suppressing GDF15 and preventing cardiac atrophy in mice.

8 citationstop 5%

mousebulk RNA-seq

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Molecular BiologybioRxivPreprintApr 10, 2024

Ergothioneine boosts mitochondrial respiration and exercise performance via direct activation of MPST

Hans‐Georg Sprenger, Melanie J. Mittenbühler, Yizhi Sun…·Bruce M. Spiegelman

This study identifies MPST as the direct target of EGT, showing it enhances mitochondrial respiration and exercise performance in mice.

7 citations

mouseproteomics

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GenomicsCirculation Genomic and Precision MedicinePeer-reviewedJul 1, 2018

Multiplexed targeted resequencing identifies coding and regulatory variation underlying phenotypic extremes of HDL-cholesterol in humans

Sumeet A. Khetarpal, Paul L. Babb, Wei Zhao…·Benjamin F. Voight

The paper uses targeted resequencing to identify rare coding and noncoding variants associated with extreme HDL-C levels in humans.

6 citations

humanwhole-exome sequencing

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