Cancer BiologyScience AdvancesPeer-reviewed
Somatic mtDNA Mutation Burden Shapes Metabolic Plasticity in Leukemogenesis
Xiujie Li-Harms, Jingjun Lü, Yu Fukuda…·Mondira Kundu
This study shows that somatic mtDNA mutations affect metabolic plasticity in leukemia development, with heterozygous mutations supporting NMyc-driven leukemia while homozygous mutations impair it.
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