Yangyang Miao

This paper introduces DiffTopo, a diffusion model for generating novel protein folds, and MirrorTopo, a pipeline to expand known fold space by mirroring native protein topologies.

This paper designs phosphorylation-induced protein switches that control transcription in cells, demonstrating their functionality in synthetic signaling.

This paper designs proteins that target neosurfaces from protein-ligand complexes using a deep learning approach, validated experimentally against three drug-bound protein complexes.

This paper introduces DiffTopo, a diffusion model for generating novel protein folds by exploring designable topology space efficiently.