Author

Horia A. Dobrila

University of IowaORCID 0009-0001-1530-4301Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Organism:C. elegans· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:development & morphogenesis· 1 Approach:experimental assay· 1 Approach:genetic perturbation / CRISPR· 1 Research Focus:host-pathogen & immune response· 1 Assay:proteomics· 1

Frequent Co-Authors

Andres J. Orea· 1 shared Andrew J. HryckowianiD· 1 shared Anthony G. Pannullo· 1 shared Craig D. EllermeieriD· 1 shared David S. WeissiD· 1 shared Facundo V. Torres· 1 shared Hannah M. Laster· 1 shared Henrieta Licha· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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1 shared paperMicrobiology

Andres J. Orea

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2 papers

Recent·Most cited

MicrobiologybioRxivPreprintJun 23, 2026

EndD mediates butyrate-dependent toxin release in Clostridioides difficile

Horia A. Dobrila, Henrieta Licha, Andrew J. Hryckowian

This study identifies EndD as the mediator of butyrate-dependent toxin release in C. difficile, showing it is regulated by SigK and not by previously known mechanisms.

DOI 10.64898/2026.06.22.733756

C. elegansproteomics

𝕏 PostBluesky

MicrobiologyJournal of BacteriologyPeer-reviewedSep 8, 2025

Analysis of Essential Genes in Clostridioides difficile by CRISPRi and Tn-seq

Maia E. Alberts, Micaila P. Kurtz, Ute Müh…·David S. Weiss

This study identifies essential genes in C. difficile using CRISPRi and Tn-seq, confirming most previously reported genes and identifying new ones, with comparisons to B. subtilis.

11 citationstop 2%

C. elegansgenetic perturbation / CRISPR

𝕏 PostBluesky