Andrew J. Hryckowian

This study identifies EndD as the mediator of butyrate-dependent toxin release in C. difficile, showing it is regulated by SigK and not by previously known mechanisms.

This study uses phage-based manipulation to reveal ecological interactions in gut microbiomes by targeting Escherichia fergusonii and analyzing its role in community dynamics.

This study establishes a murine model of Group B Streptococcus colonization in the adult gastrointestinal tract and identifies the GBS capsule as a critical colonization factor.

This study investigates the impact of a perR mutation on oxygen sensitivity, gene expression, and infection in C. difficile 630Δerm, finding no difference in infection outcomes but altered gene expression under ambient oxygen.

The paper develops a metagenomics pipeline to study insertion sequence (IS) elements in the microbiota, revealing their role in bacterial genome diversification and adaptation.