Author

Jacob Giehm Mikkelsen

Aarhus UniversityORCID 0000-0002-1322-3209Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cell Biology· 1 Genetics· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 2 Approach:experimental assay· 2 Organism:human· 2 Assay:bulk RNA-seq· 1 Assay:CRISPR screen· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

Anne Bruun RovsingiD· 1 shared Anton MarkoviD· 1 shared Diana SharyshiD· 1 shared Emil Aagaard ThomseniD· 1 shared Huiqiang Cai· 1 shared Ian Helstrup NielseniD· 1 shared Jacob Fog BentzoniD· 1 shared Jakob HaldrupiD· 1 shared

Activity by Year

2022-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 14 mutual co-author links

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1 shared paperImmunology

Anne Bruun RovsingORCID

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3 papers

Recent·Most cited

Loss of physiological stretch elicits an inflammatory, plaque-like transcriptional state in cultured human aortic smooth muscle cells

Lise Filt Jensen, Anton Markov, Laura Alonso-Herranz, Diana Sharysh, Emil Aagaard Thomsen, Jacob Giehm Mikkelsen, Jacob Fog Bentzon, Julián Albarrán-Juárez

This study shows that physiological stretch reduces inflammation in cultured human aortic smooth muscle cells, while static culture or excessive stretch promotes an inflammatory, plaque-like state.

bioRxiv · Oct 29, 2025 · PreprintCell Biology

Multiparametric optimization of human primary B-cell cultures using Design of Experiments

Anne Bruun Rovsing, Kenneth Green, Lisbeth Jensen, Ian Helstrup Nielsen, Jacob Giehm Mikkelsen, Søren Egedal Degn

This study optimizes human primary B-cell culture conditions using Design of Experiments, identifying CD40L and IL-4 as critical factors for viability and IgE class-switching.

Scandinavian Journal of Immunology · Jul 28, 2025Peer-reviewedImmunology

A truncated reverse transcriptase enhances prime editing by split AAV vectors

Zongliang Gao, Sujan Ravendran, Nanna S. Mikkelsen, Jakob Haldrup, Huiqiang Cai, Xiangning Ding, Søren R. Paludan, Martin Kristian Thomsen, Jacob Giehm Mikkelsen, Rasmus Otkjær Bak

This paper improves prime editing by modifying the reverse transcriptase component to enhance efficiency and enable delivery via split AAV vectors.

Molecular Therapy · Jul 8, 2022Peer-reviewedGenetics