ImmunologybioRxivPreprint
Structure basis for distinct protective mechanisms of IGHV3-23 antibodies targeting influenza hemagglutinin stem
Huibin Lv, Yang Wei Huan, Tossapol Pholcharee…·Nicholas C. Wu
This study identifies three IGHV3-23 antibodies targeting influenza HA stem, showing that non-neutralizing antibodies with enhanced Fc-mediated effector functions offer better in vivo protection than a potent neutralizer.
DOI 10.1101/2025.11.06.687086