Bo Ding

The paper identifies essential regulatory elements that maintain chromatin organization and cell viability through their role in 3D chromatin contacts, showing that non-essential genes can synergize to cause cell death.

The paper identifies non-coding genomic regions critical for chromatin organization and cell viability, showing their structural importance despite lacking epigenomic signals or annotated elements.

The paper systematically maps chromatin state landscapes during mouse development by profiling histone modifications across 72 tissue-stages, identifying dynamic enhancers and transcriptional regulators.

This study evaluates seven single cell RNA-seq normalization methods using diluted RNA data, finding that methods incorporating spike-in ERCC RNA outperform those without.

This study evaluates the performance of three scRNA-seq methods through controlled experiments, finding they reliably detect genes above 5-10 molecules with linear measurement transfer functions.

The paper identifies cancer-specific genotype variations that target 3D chromosomal hubs, altering local interactions and revealing principles of genome organization.