Ying Liu

Massively parallel interrogation of human functional variants modulating cancer immunosurveillance

The paper identifies functional mutations affecting PD-L1 and HLA-I expression using a large-scale CRISPR screen, revealing clinically relevant variants that influence immunotherapy response.

Prime editor-based high-throughput screening reveals functional synonymous mutations in the human genome

The paper uses Prime editor-based screening to identify functional synonymous mutations in the human genome, showing some affect cell fitness and biological processes.

Regulatory elements can be essential for maintaining broad chromatin organization and cell viability

The paper identifies essential regulatory elements that maintain chromatin organization and cell viability through their role in 3D chromatin contacts, showing that non-essential genes can synergize to cause cell death.

Non-coding loci without epigenomic signals can be essential for maintaining global chromatin organization and cell viability

The paper identifies non-coding genomic regions critical for chromatin organization and cell viability, showing their structural importance despite lacking epigenomic signals or annotated elements.