Wensheng Wei

This paper introduces PDLMs, protein-DNA language models that jointly represent protein and DNA sequences to predict and engineer DNA recognition specificity.

This paper develops eTd-mtABEs, engineered mitochondrial A-to-G base editors with enhanced efficiency and targeting scope, enabling efficient generation of mtDNA disease models in rat embryos.

The paper identifies functional mutations affecting PD-L1 and HLA-I expression using a large-scale CRISPR screen, revealing clinically relevant variants that influence immunotherapy response.

The paper identifies co-occurring mutations in cancer genomes using FP-Growth, revealing 100,933 mutation pairs across 22 cancer types and highlighting potential therapeutic targets.

The paper uses Prime editor-based screening to identify functional synonymous mutations in the human genome, showing some affect cell fitness and biological processes.

The paper identifies essential regulatory elements that maintain chromatin organization and cell viability through their role in 3D chromatin contacts, showing that non-essential genes can synergize to cause cell death.

The paper identifies non-coding genomic regions critical for chromatin organization and cell viability, showing their structural importance despite lacking epigenomic signals or annotated elements.

This paper introduces LEAPER, a method using endogenous ADAR proteins for targeted RNA editing, demonstrating its efficacy in restoring p53 function and catalytic activity in disease models.