Lina Zheng

Comprehensive multimodal and multiomic profiling reveals epigenetic and transcriptional reprogramming in lung tumors

The paper integrates epigenomic and transcriptomic data from lung tumors and non-neoplastic tissues to identify cancer-related signaling networks and regulatory changes.

Regulation associated modules reflect 3D genome modularity associated with chromatin activity

The paper identifies regulation associated modules (RAMs) from histone modifications that reflect 3D chromatin modularity aligned with chromatin activity, showing stronger insulation and functional relevance compared to TADs.

Regulatory elements can be essential for maintaining broad chromatin organization and cell viability

The paper identifies essential regulatory elements that maintain chromatin organization and cell viability through their role in 3D chromatin contacts, showing that non-essential genes can synergize to cause cell death.

Non-coding loci without epigenomic signals can be essential for maintaining global chromatin organization and cell viability

The paper identifies non-coding genomic regions critical for chromatin organization and cell viability, showing their structural importance despite lacking epigenomic signals or annotated elements.